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控制再生过程的“基因开关”想打开吗?

□ 时间:2019-3-20 □ 来源: 领研网


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    摘要:Whole-body regeneration is accompanied by complex transcriptomic changes, yet the chromatin regulatory landscapes that mediate this dynamic response remain unexplored. To decipher the regulatory logic that orchestrates regeneration, we sequenced the genome of the acoel worm Hofstenia miamia, a highly regenerative member of the sister lineage of other bilaterians. Epigenomic profiling revealed thousands of regeneration-responsive chromatin regions and identified dynamically bound transcription factor motifs, with the early growth response (EGR) binding site as the most variably accessible during Hofstenia regeneration. Combining egr inhibition with chromatin profiling suggests that Egr functions as a pioneer factor to directly regulate early wound-induced genes. The genetic connections inferred by this approach allowed the construction of a gene regulatory network for whole-body regeneration, enabling genomics-based comparisons of regeneration across species.
    摘要:全身再生伴随着复杂的转录组学变化,但介导这种动态反应的染色质调节环境仍未得到探索。 为了破译协调再生的监管逻辑,我们对霍布斯特氏菌(Hofstenia miamia)的基因组进行了测序,这是其他双子宫的姊妹血统的高度再生成员。 表观遗传学分析揭示了数千个再生响应染色质区域并鉴定了动态结合的转录因子基序,早期生长反应(EGR)结合位点是霍夫替尼再生期间最易变的。 结合egr抑制和染色质分析表明Egr作为直接调节早期伤口诱导基因的先驱因子起作用。 通过这

资讯作者: Andrew R. Gehrke 源信息发布时间: 2019/3/19 编辑:金阳
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